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Despite its advantages, its important to acknowledge GHK-Cus limitations when compared to traditional acne treatments in a research context: Limited Direct Evidence for Active Acne Vulgaris: While it has anti-inflammatory properties, there is currently limited direct clinical evidence specifically demonstrating GHK-Cu as a primary treatment for active acne breakouts (e.g., reducing papules, pustules, or cysts)

Unlike fat-soluble vitamins (A, D, E, and K), which are stored in fat tissue for long periods, water-soluble vitamins are processed relatively quickly: your body takes what it needs, stores a small amount in the liver, and passes most of the rest in urine